COVID-19 vaccine studies
Investigating a Vaccine Against COVID-19 (COV002)
A phase 2/3 study to determine the efficacy, safety and immunogenicity of the candidate Coronavirus Disease (COVID-19) vaccine ChAdOx1 nCoV-19
Sponsor: University of Oxford
Site: Aneurin Bevan University Health Board Location: Newport
ENSEMBLE 2 - Phase 3 COVID-19 Vaccine Study - VAC31518COV3009
A Randomized, Double-blind, Controlled Phase 3 Study to Assess the Efficacy and Safety of Ad26.COV2.S for the Prevention of SARS-CoV-2-mediated COVID-19 in Adults Aged 18 Years and Older
Sponsor: Janssen-Cilag Ltd
Site: Public Health Wales Location: Cardiff
Sponsor: NOVAVAX, INC.
Site: Public Health Wales Location: Wrexham
Coronavirus-Like Particle COVID-19 Vaccine (CP-PRO-CoVLP-021)
Sponsor: Medicago Inc
A Randomized, Observer-Blind, Placebo-Controlled, Phase 2/3 Study to Assess the Safety, Efficacy, and Immunogenicity of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine in Adults 18 Years of Age or Older
This study sponsored by Medicago Inc. will evaluate an experimental vaccine to see if it can help prevent or control COVID-19 infections. The study will evaluate the efficacy and safety of the Coronavirus-Like Particle COVID-19 Vaccine. Participants will receive 2 doses of the experimental vaccine (CoVLP vaccine combined with the adjuvant AS03 CoVLP formulation) and 2 doses of placebo (dummy drug).
Up to 30000 participants will be enrolled in the study. The study will be conducted at multiple sites in the United States, Canada, United Kingdom, Europe and Latin America.
Site: Public Health Wales Location: Wrexham
ComFluCov - A single-blind, phase IV UK multi-centre randomised controlled trial to determine reactogenicity and immunogenicity of COVID-19 vaccines administered concomitantly with seasonal influenza vaccine
The ComFluCOV trial will determine the safety, as well as the immune responses, to administration of the currently approved COVID-19 vaccines at the same time as the recommended influenza vaccines from the 2020/21 season.
Site: Public Health Wales Location: Cardiff and Vale University Health Board
Evaluating COVID-19 Vaccine Boosters (Cov-Boost)
A randomised, phase II UK multi-centre study to determine reactogenicity and immunogenicity of booster vaccination against ancestral and novel variants of SARS-CoV-2
Site: Public Health Wales Location: Wrexham
Comparing Covid-19 Vaccine Schedule Combinations in Adolescents. A single-blind, randomised, phase II multi-centre study to determine reactogenicity and immunogenicity of heterologous prime/boost Covid-19 vaccine schedules in adolescents.
Site: Cardiff and Vale University Health Board