COVID-19 research in Wales

COVID-19 research in Wales

The following Coronavirus COVID-19 related research studies are active or are in set up in Wales: 

 

Open and recruiting – Urgent Public Health (UPH) studies

 

Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial

The Randomised Evaluation of COVID Therapy (RECOVERY) trial will test if existing or new drugs can help patients hospitalised with confirmed COVID-19.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board, Velindre University NHS Trust


COVID-19: ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C) / CCP-UK Clinical Characterisation Protocol for Severe Emerging Infection

The researchers will collect samples and data from COVID-19 patients in the UK to answer many urgent questions about the virus in real time.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


REMAP-CAP: a platform trial for severely ill patients with COVID-19

A randomised controlled trial for patients admitted to the intensive care unit (ICU) with severe Community-Acquired Pneumonia (CAP). This trial studies a number of different treatment categories under one platform with an aim to determine the best package of treatment for patients.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Swansea Bay University Health Board


Pandemic Respiratory Infection Emergency System Triage (PRIEST) study

Pandemic Respiratory Infection Emergency System Triage (previously: The PAINTED study: Pandemic Influenza Triage in the Emergency Department).

Open in: Aneurin Bevan University Health Board


UK Obstetric Surveillance System (UKOSS)

Maternal and Perinatal Outcomes of Pandemic Influenza in Pregnancy.

Open in: all Health Boards in Wales


Evaluation and refinement of pandemic influenza community assessment tools (FLU-CATs)

Real time refinement and validation of criteria and tools used in primary care to aid hospital referral decisions for patients of all ages in the event of surge during an influenza pandemic.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Powys Teaching Health Board, Swansea Bay University Health Board


Genetics of susceptibility and mortality in critical care (GenOMICC)

Our genes determine how susceptible we are to life-threatening infection. When a patient is already sick, different genetic factors determine how likely they are to survive. The GenOMICC (Genetics of Susceptibility and Mortality in Critical Care) study will identify the specific genes that cause some people to be susceptible to specific infections and consequences of severe injury.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board, Swansea Bay University Health Board


RECOVERY - Respiratory Support

This study is aiming to determine if continuous positive airway pressure (CPAP) or high flow nasal oxygen (HFNO) is clinically effective compared to standard care (excluding CPAP or HFNO).

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board


Neonatal Complications of Coronavirus Disease (COVID-19) Study

This is a national surveillance programme using the standard British Paediatric Surveillance Unit (BPSU) approach. This study will run alongside and be cross-linked with the maternal surveillance study run through the United Kingdom Obstetric Surveillance System (UKOSS; CPMS: 14162), which is already in progress.

Open in: all Health Boards in Wales


Pregnancy and Neonatal Outcomes in COVID-19

To better understand some specific research questions as to how COVID-19 affects early pregnancy, fetal growth, prematurity and virus transmission to the baby the researchers will construct a registry of women with suspected and confirmed COVID-19.

Open in: Aneurin Bevan University Health Board, Betsi Cadwaladr University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Swansea Bay University Health Board


Investigating a Vaccine Against COVID-19 (COV002)

A phase 2/3 study to determine the efficacy, safety and immunogenicity of the candidate Coronavirus Disease (COVID-19) vaccine ChAdOx1 nCoV-19. This study will enable us to assess how well people of all ages can be protected from COVID-19 with this new vaccine called ChAdOx1 nCoV-19. It will also give us valuable information on safety aspects of the vaccine and its ability to generate good immune responses against the virus. In total we will enrol up to 5260 volunteers.

Open in: Aneurin Bevan University Health Board, Public Health Wales


Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE)

The trial aims to give a rapid answer about the effectiveness of hydroxychloroquine in modifying the disease course of COVID-19.

Open: Wales wide


Phase 3 multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of canakinumab on cytokine release syndrome in patients with COVID-19-induced pneumonia (CAN-COVID)

Open in: Cardiff and Vale University Health Board


Multiarm Therapeutic study in pre-ICU patients admitted with COVID-19 - Repurposed Drugs (TACTIC-R)

TACTIC is recruiting patients at an early stage of COVID-19 disease course, aiming for a time point where the patient is experiencing infective symptoms and starting to show pulmonary complications. The purpose is to prevent organ damage and reduce the need to transfer to ICU and ventilation. The aim of this trial is to reduce the number of COVID-19 patients that will be admitted to ICU.

Open in: Cardiff and Vale University Health Board


The effectiveness and cost-effectiveness of a group programme for men who are concerned about their abusive behaviour in relationships with women: A randomised controlled trial (REPROVIDE)

This study has been open to recruitment since October 2019, and forms part of an NIHR programme grant called 'Reaching Everyone: Programme of Research on Violence in Diverse Domestic Environments' (REPROVIDE). It has been repurposed in light of COVID-19 as the victim support and signposting services to partners and ex-partners, and the identification and monitoring of abusive men that are provided within the context of the study are vitally important services to continue.

Open: Wales wide


CATALYST: A randomised phase II proof of principle multi-arm multi-stage trial designed to guide the selection of interventions for phase III trials in hospitalised patients with COVID-19 infection

This is a clinical trial where participants will be randomly allocated to one of several possible new treatments for COVID-19.

Open: Cardiff and Vale University Health Board, Swansea Bay University Health Board


STOP-COVID19

This clinical trial is designed to evaluate the potential of Brensocatib (INS1007) as a novel host directed therapy for the treatment of adult patients hospitalized with COVID-19. 

Open: Cardiff and Vale University Health Board