Completed studies
Multiarm Therapeutic study in pre-ICU patients admitted with COVID-19 - Repurposed Drugs (TACTIC-R)
TACTIC is recruiting patients at an early stage of COVID-19 disease course, aiming for a time point where the patient is experiencing infective symptoms and starting to show pulmonary complications. The purpose is to prevent organ damage and reduce the need to transfer to ICU and ventilation. The aim of this trial is to reduce the number of COVID-19 patients that will be admitted to ICU.
Completed in: Cardiff and Vale University Health Board
BREATHE: B cell Receptor Evaluation for Antibodies to proTect Human Exposure to SARS-COV-2
PROJECT BREATHE aims to bring together a coalition of companies, academics, NHS and public sector across the UK and internationally to generate large numbers of doses of therapeutic antibodies against COVID19. In order to be successful, we need to source samples from patients with a range of responses to viral infection.
Completed in: Cardiff and Vale University Health Board
ATOMIC2
The ATOMIC2 study is investigating if a common antibiotic called Azithromycin (AZM) may prevent the patients from getting worse.
Completed in: Cardiff and Vale University Health Board
Paramedic Experiences of providing Care during the 2020 COVID-19 Pandemic (PECC-19): A qualitative study using Grounded Theory
Completed in: Welsh Ambulance Services NHS Trust
Characterisation of the immune response to SARSCoV2 in Type 1 diabetes.
The aim of this project is to understand the host immune response to infection with SARS-CoV-2 over time in convalescent newly diagnosed patients with type 1 diabetes.
Completed in: Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board
Understanding NHS staff mental health during COVID-19
Understanding the experiences of the COVID-19 pandemic on NHS staff mental health, workplace characteristics and resilience: A longitudinal view.
Completed in: Hywel Dda University Health Board
The CTEX WG5 (COVID-19 CPAP) MULTI SITE DEVICE INVESTIGATION
This study seeks to trial the use of a new continuous positive airway pressure (CPAP) device, known as the CTEX-WG5, on COVID-19 patients in hospitals in Wales.
Completed in: Aneurin Bevan University Health Board, Cardiff and Vale University Health Board, Cwm Taf Morgannwg University Health Board, Hywel Dda University Health Board
Characterising the immune response in COVID-19
This research will look at the immune system response in a range of hospitalised COVID-19 patients and in biobanked samples using very advanced blood analysis not normally available in hospital settings. We hope to identify patterns of immune response in people with COVID-19 at different stages / severity of illness.
Completed in: Hywel Dda University Health Board
Mass spec analysis of metabolites in blood from Covid-19 patients
Exploratory clinical and laboratory study: quantitative analysis of metabolites in clinical samples from Covid-19 patients.
Completed in: Hywel Dda University Health Board
Completed in: Cardiff and Vale University Health Board
This clinical trial is designed to evaluate the potential of Brensocatib (INS1007) as a novel host directed therapy for the treatment of adult patients hospitalized with COVID-19.
Completed in: Cardiff and Vale University Health Board
CARA study
This study will recruit UK ambulance staff to complete a short online questionnaire assessing their current perceived preparedness and wellbeing during the current accelerative phase of COVID-19 outbreak
Completed in: Welsh Ambulance Service NHS Trust
COVID-19 & Stress Study
The aim of our research is to (i) understand the magnitude and nature of the psychological harm inflicted by the pandemic; (ii) examine the potential for it to translate into physical harm; and (iii) provide evidence to inform how these harms may be mitigated.
Completed in: Cwm Taf Morgannwg University Health Board
Covid-Nurse: staff survey, version 1
Covid-Nurse: a staff survey of meeting SARS-CoV-2 patients' fundamental nursing care needs.
Completed in: Cwm Taf Morgannwg University Health Board
CovidOvPsych study
A longitudinal mixed methods study of the psychological impact of the COVID-19 crisis on women undergoing treatment for ovarian cancer
Completed in: Cardiff and Vale University Health Board
CovPall: palliative care for those with COVID-19 (v1.0)
This research aims to rapidly evaluate the palliative care response in COVID-19 to improve care now and in the future.
Completed in: Cardiff and Vale University Health Board
Expanded Access Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection
Completed in: Cardiff and Vale University Health Board
PROTECT-ASUC
Covid-19 Pandemic response of assessment, endoscopy and treatment in Acute Sever Ulcerative Colitis. A multi-center observational case-control study.
Completed in: Cardiff and Vale University Health Board
The COMPARE study
The impact of COVID-19 on Emergency Medical Service led out of hospital cardiac arrest resuscitation: A Qualitative study.
Completed in: Welsh Ambulance Services NHS Trust
UNITE-COVID
EUROPEAN SOCIETY OF INTENSIVE CARE MEDICINE COVID-19 Project
Completed in: Hywel Dda University Health Board
ACCORD-2-003
ACCORD 2: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID 19 in Hospitalised Patients.
Completed in: Aneurin Bevan University Health Board